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 Pharmacology of Tetracycline Introduction       Tetracycline, sold under the brand name Sumycin among others, is an oral antibiotic in the tetracyclines family of medications, used to treat a number of infections, including acne, cholera, brucellosis, plague, malaria, and syphilis. Common side effects include vomiting, diarrhea, rash, and loss of appetite.  Formula :  C 22 H 24 N 2 O 8 IUPAC ID :  (4S,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide Molar mass :  444.435 g/mol CAS ID :  60-54-8 Elimination half-life :  8–11 hours, 57–108 hours (kidney impairment) Metabolism :  Not metabolized DOSAGES OF TETRACYCLINE Capsule / Tablet 250  mg 500 mg Syrup (extemporaneously prepared) 125mg/5mL 5 mg Dosage Considerations – Should be Given as Follows: Chronic Bronchitis ,  Acute   Exacerbation 500 mg orally every 6 hours Acne 250-50...

 CARBAMAZEPINE Introduction Medication Carbamazepine, sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder. IUPAC ID: 5H-dibenzo[b,f]azepine-5-carboxamide   Formula: C15H12N2O CAS ID: 298-46-4   Molar mass: 236.269 g/mol   Drug class: Anticonvulsant   Elimination half-life : 36 hours (single dose), 16-24 hours (repeated dosing).

 ARTEMETHER-LUMEFANTRINE (COARTEM ®)  Pharmacology and Metabolism Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg. Coartem can cause anaphylactic reactions. The drug frequently causes headache, dizziness and anorexia, although mild forms in most cases. Other fairly common side effects (more than 3% of patients) include sleep disorder, tinnitus, tremor, palpitation, as well as unspecific reactions like vertigo, gastrointestinal disorders, itch and nasopharyngitis. Mechanism of action Involves an interaction with ferriprotoporphyrin IX (“heme”), or ferrous ions, in the acidic parasite food vacuole, which results in the generation of cytotoxic radical species. The general...

What is Piroxicam? Piroxicam is a nonsteroidal anti-inflammatory drug of the oxicam class used to relieve the symptoms of painful inflammatory conditions like arthritis. Piroxicam works by preventing the production of endogenous prostaglandins which are involved in the mediation of pain, stiffness, tenderness and swelling.  Molar mass: 331.348 g/mol Formula: C15H13N3O4S CAS ID: 36322-90-4 The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose, take it more often, or take it for a longer time than prescribed. If you are taking this drug "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well. Nonsteroidal anti-inflammatory drugs (including...

  What Is Feldene? Feldene (piroxicam) is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis. What Are Side Effects of Feldene? Side effects of Feldene are: swelling, anorexia, abdominal pain, constipation, diarrhea, indigestion, heartburn, upset stomach, stomach pain, elevated liver enzymes, bloating, gas, gross bleeding/perforation, heartburn, nausea, ulcers (gastric/duodenal), dizziness, headache, nervousness, skin itching or rash, blurred vision, ringing in your ears, Drugs Substances, or Supplements Interact with Feldene Feldene may interact with alcohol, antidepressants, blood thinners, lithium, methotrexate, diuretics (water pills), steroids, aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), or ACE inhibitors. Tell your doctor all medications and supplements you use.